Resource leads

Christine Orengo obtained a PhD in Enzyme Kinetics from UCL, London. She was awarded an MRC Senior Research Fellowship 1995-2015 and was appointed Professor in Bioinformatics at UCL in 2002. Christine Orengo’s research focuses on how proteins evolve – how do relatives in a family diverge in structure and function and how do they evolve to operate in different biological contexts. The CATH classification, developed together with Janet Thornton, is widely accessed (nearly 2 million webpage accesses and 10,000 unique visitors per month) and a partner resource in InterPro. CATH was enabled by the development of robust protein structure comparison algorithms and is widely used by the structural biology and structural genomics communities.

Analysis of CATH led to important insights into the population and diversity of structural families and folds. More recently, with the assignment of 55 million domains to CATH, sequence analysis has enabled the recognition of functional subfamilies possessing distinct sequence patterns that can aid function prediction. CATH domain families have also been exploited in the prediction and analysis of protein networks and the group collaborate with several experimental groups characterising signalling networks implicated in development, neuropathic pain and cancer. Christine Orengo is a member of EMBO and a Vice-President of the International Society for Computational Biology.

Christine Orengo photo